| 1 | Georgia Southern over South Alabama 52–0 · at home · 2017-11-18 | 2017 | +6 | +58.0 | 35% | — |
| 2 | Iowa over #3Ohio State 55–24 · at home · 2017-11-04 | 2017 | +21 | +52.0 | 9% | 27 |
| 3 | California over #8Washington State 37–3 · at home · 2017-10-14 | 2017 | +16.5 | +50.5 | 15% | 22 |
| 4 | Howard over UNLV 43–40 · on the road · 2017-09-03 | 2017 | +45 | +48.0 | 0.3% | — |
| 5 | Louisiana Tech over SMU 51–10 · neutral site · 2017-12-21 | 2017 | +4 | +45.0 | 40% | — |
| 6 | Tulsa over Houston 45–17 · at home · 2017-10-14 | 2017 | +13.5 | +41.5 | 20% | — |
| 7 | Fresno State over New Mexico 38–0 · at home · 2017-10-15 | 2017 | +2.5 | +40.5 | 44% | — |
| 8 | App State over Toledo 34–0 · neutral site · 2017-12-24 | 2017 | +6 | +40.0 | 35% | — |
| 9 | Boston College over Florida State 35–3 · at home · 2017-10-28 | 2017 | +6 | +38.0 | 35% | — |
| 10 | Purdue over Missouri 35–3 · on the road · 2017-09-16 | 2017 | +5.5 | +37.5 | 37% | — |
| 11 | Mississippi State over #12LSU 37–7 · at home · 2017-09-16 | 2017 | +7.5 | +37.5 | 32% | 18 |
| 12 | Iowa State over #3Oklahoma 38–31 · on the road · 2017-10-07 | 2017 | +30.5 | +37.5 | 3% | 27 |
| 13 | Boston College over Virginia 41–10 · on the road · 2017-10-21 | 2017 | +6.5 | +37.5 | 34% | — |
| 14 | Minnesota over Oregon State 48–14 · on the road · 2017-09-10 | 2017 | +2.5 | +36.5 | 44% | — |
| 15 | Idaho State over Nevada 30–28 · on the road · 2017-09-16 | 2017 | +34.5 | +36.5 | 2% | — |
| 16 | #7Miami over #3Notre Dame 41–8 · at home · 2017-11-12 | 2017 | +3.5 | +36.5 | 41% | 4 |
| 17 | Liberty over Baylor 48–45 · on the road · 2017-09-02 | 2017 | +33 | +36.0 | 2% | — |
| 18 | UNLV over Idaho 44–16 · on the road · 2017-09-09 | 2017 | +4.5 | +32.5 | 39% | — |
| 19 | Virginia over Boise State 42–23 · on the road · 2017-09-23 | 2017 | +13.5 | +32.5 | 20% | — |
| 20 | UCF over Maryland 38–10 · on the road · 2017-09-23 | 2017 | +4.5 | +32.5 | 39% | — |
| 21 | East Carolina over Cincinnati 48–20 · at home · 2017-11-18 | 2017 | +4.5 | +32.5 | 39% | — |
| 22 | UNLV over Fresno State 26–16 · on the road · 2017-10-29 | 2017 | +21.5 | +31.5 | 9% | — |
| 23 | Ohio over Toledo 38–10 · at home · 2017-11-09 | 2017 | +3 | +31.0 | 43% | — |
| 24 | Fresno State over San Diego State 27–3 · on the road · 2017-10-22 | 2017 | +6.5 | +30.5 | 34% | — |
| 25 | Arizona State over Utah 30–10 · on the road · 2017-10-21 | 2017 | +10 | +30.0 | 27% | — |
| 26 | South Carolina over Arkansas 48–22 · at home · 2017-10-07 | 2017 | +3.5 | +29.5 | 41% | — |
| 27 | Texas State over Coastal Carolina 27–7 · on the road · 2017-10-28 | 2017 | +9.5 | +29.5 | 28% | — |
| 28 | Duke over Georgia Tech 43–20 · at home · 2017-11-18 | 2017 | +6.5 | +29.5 | 34% | — |
| 29 | Georgia State over Charlotte 28–0 · on the road · 2017-09-23 | 2017 | +1 | +29.0 | 48% | — |
| 30 | South Alabama over Troy 19–8 · on the road · 2017-10-12 | 2017 | +18 | +29.0 | 13% | — |
| 31 | UAB over Southern Miss 30–12 · on the road · 2017-10-28 | 2017 | +11 | +29.0 | 25% | — |
| 32 | Maryland over #23Texas 51–41 · on the road · 2017-09-02 | 2017 | +18.5 | +28.5 | 12% | 7 |
| 33 | Utah State over UNLV 52–28 · on the road · 2017-10-21 | 2017 | +3.5 | +27.5 | 41% | — |
| 34 | Army over Air Force 21–0 · on the road · 2017-11-04 | 2017 | +6.5 | +27.5 | 34% | — |
| 35 | Syracuse over #2Clemson 27–24 · at home · 2017-10-13 | 2017 | +24 | +27.0 | 7% | 28 |
| 36 | Florida International over Western Kentucky 41–17 · at home · 2017-11-25 | 2017 | +3 | +27.0 | 43% | — |
| 37 | Air Force over Colorado State 45–28 · on the road · 2017-10-28 | 2017 | +9.5 | +26.5 | 28% | — |
| 38 | Duke over Northwestern 41–17 · at home · 2017-09-09 | 2017 | +1.5 | +25.5 | 46% | — |
| 39 | Florida International over Tulane 23–10 · at home · 2017-10-14 | 2017 | +12.5 | +25.5 | 22% | — |
| 40 | Florida International over Marshall 41–30 · on the road · 2017-10-28 | 2017 | +14.5 | +25.5 | 18% | — |
| 41 | #10Auburn over #2Georgia 40–17 · at home · 2017-11-11 | 2017 | +2.5 | +25.5 | 44% | 8 |
| 42 | Kentucky over Vanderbilt 44–21 · on the road · 2017-11-11 | 2017 | +2.5 | +25.5 | 44% | — |
| 43 | Wake Forest over Boston College 34–10 · on the road · 2017-09-09 | 2017 | +1 | +25.0 | 48% | — |
| 44 | Iowa State over Texas Tech 31–13 · on the road · 2017-10-21 | 2017 | +7 | +25.0 | 33% | — |
| 45 | Bowling Green over Miami (OH) 37–29 · on the road · 2017-10-07 | 2017 | +16.5 | +24.5 | 15% | — |
| 46 | Kansas State over #10Oklahoma State 45–40 · on the road · 2017-11-18 | 2017 | +19.5 | +24.5 | 11% | 20 |
| 47 | Arizona State over #5Washington 13–7 · at home · 2017-10-15 | 2017 | +18 | +24.0 | 13% | 25 |
| 48 | #16TCU over #6Oklahoma State 44–31 · on the road · 2017-09-23 | 2017 | +10.5 | +23.5 | 26% | 10 |
| 49 | Troy over #25LSU 24–21 · on the road · 2017-09-30 | 2017 | +20.5 | +23.5 | 10% | 5 |
| 50 | North Texas over Southern Miss 43–28 · on the road · 2017-09-30 | 2017 | +8 | +23.0 | 31% | — |
| 51 | Boston College over Louisville 45–42 · on the road · 2017-10-14 | 2017 | +20 | +23.0 | 11% | — |
| 52 | Oregon over Utah 41–20 · at home · 2017-10-28 | 2017 | +2 | +23.0 | 45% | — |
| 53 | #5Oklahoma over #2Ohio State 31–16 · on the road · 2017-09-09 | 2017 | +7.5 | +22.5 | 32% | 3 |
| 54 | Boise State over #19San Diego State 31–14 · on the road · 2017-10-15 | 2017 | +5.5 | +22.5 | 37% | 11 |
| 55 | Tennessee State over Georgia State 17–10 · on the road · 2017-08-31 | 2017 | +15 | +22.0 | 17% | — |
| 56 | Pittsburgh over #2Miami 24–14 · at home · 2017-11-24 | 2017 | +12 | +22.0 | 23% | 28 |
| 57 | San José State over Wyoming 20–17 · at home · 2017-11-25 | 2017 | +19 | +22.0 | 12% | — |
| 58 | East Carolina over BYU 33–17 · at home · 2017-10-21 | 2017 | +5.5 | +21.5 | 37% | — |
| 59 | Central Michigan over Kansas 45–27 · on the road · 2017-09-09 | 2017 | +3 | +21.0 | 43% | — |
| 60 | New Mexico over Air Force 56–38 · at home · 2017-09-30 | 2017 | +3 | +21.0 | 43% | — |
