| 1 | Nevada over San José State 55–10 · at home · 2025-11-15 | 2025 | +9.5 | +54.5 | 28% | — |
| 2 | San Diego State over California 34–0 · at home · 2025-09-21 | 2025 | +14 | +48.0 | 19% | — |
| 3 | Louisville over Kentucky 41–0 · at home · 2025-11-29 | 2025 | +1.5 | +42.5 | 46% | — |
| 4 | New Mexico over UCLA 35–10 · on the road · 2025-09-13 | 2025 | +15.5 | +40.5 | 17% | — |
| 5 | Fresno State over Boise State 30–7 · on the road · 2025-11-01 | 2025 | +17.5 | +40.5 | 14% | — |
| 6 | Marshall over Old Dominion 48–24 · at home · 2025-10-11 | 2025 | +14.5 | +38.5 | 18% | — |
| 7 | Hawai'i over San Diego State 38–6 · at home · 2025-11-09 | 2025 | +6.5 | +38.5 | 34% | — |
| 8 | UTSA over East Carolina 58–24 · at home · 2025-11-22 | 2025 | +2 | +36.0 | 45% | — |
| 9 | Austin Peay over Middle Tennessee 34–14 · on the road · 2025-08-30 | 2025 | +15.5 | +35.5 | 17% | — |
| 10 | Kentucky over Florida 38–7 · at home · 2025-11-09 | 2025 | +4.5 | +35.5 | 39% | — |
| 11 | Colorado State over Fresno State 49–21 · at home · 2025-10-11 | 2025 | +5.5 | +33.5 | 37% | — |
| 12 | South Florida over #25Boise State 34–7 · at home · 2025-08-28 | 2025 | +5.5 | +32.5 | 37% | 5 |
| 13 | Coastal Carolina over South Alabama 38–20 · on the road · 2025-09-20 | 2025 | +14.5 | +32.5 | 18% | — |
| 14 | Kennesaw State over Louisiana Tech 35–7 · at home · 2025-10-09 | 2025 | +4.5 | +32.5 | 39% | — |
| 15 | UCLA over Michigan State 38–13 · on the road · 2025-10-11 | 2025 | +7 | +32.0 | 33% | — |
| 16 | Syracuse over Clemson 34–21 · on the road · 2025-09-20 | 2025 | +17.5 | +30.5 | 14% | — |
| 17 | UAB over #22Memphis 31–24 · at home · 2025-10-18 | 2025 | +23.5 | +30.5 | 7% | 8 |
| 18 | Texas State over Southern Miss 41–14 · on the road · 2025-11-15 | 2025 | +3 | +30.0 | 43% | — |
| 19 | UCLA over #7Penn State 42–37 · at home · 2025-10-04 | 2025 | +24.5 | +29.5 | 6% | 23 |
| 20 | #24South Florida over North Texas 63–36 · on the road · 2025-10-10 | 2025 | +2.5 | +29.5 | 44% | — |
| 21 | New Mexico State over Sam Houston 37–10 · at home · 2025-10-03 | 2025 | +2 | +29.0 | 45% | — |
| 22 | Florida International over Western Kentucky 25–6 · on the road · 2025-10-15 | 2025 | +10 | +29.0 | 27% | — |
| 23 | Kansas State over Kansas 42–17 · on the road · 2025-10-25 | 2025 | +3.5 | +28.5 | 41% | — |
| 24 | UTSA over Tulane 48–26 · at home · 2025-10-30 | 2025 | +6 | +28.0 | 35% | — |
| 25 | Florida State over #8Alabama 31–17 · at home · 2025-08-30 | 2025 | +13.5 | +27.5 | 20% | 22 |
| 26 | #17Texas Tech over #16Utah 34–10 · on the road · 2025-09-20 | 2025 | +3.5 | +27.5 | 41% | 1 |
| 27 | Maryland over Wisconsin 27–10 · on the road · 2025-09-20 | 2025 | +10.5 | +27.5 | 26% | — |
| 28 | Buffalo over Bowling Green 28–3 · on the road · 2025-11-01 | 2025 | +2.5 | +27.5 | 44% | — |
| 29 | Florida International over Middle Tennessee 56–30 · on the road · 2025-11-08 | 2025 | +1.5 | +27.5 | 46% | — |
| 30 | Long Island University over Eastern Michigan 28–23 · on the road · 2025-09-06 | 2025 | +22 | +27.0 | 8% | — |
| 31 | Vanderbilt over #11South Carolina 31–7 · on the road · 2025-09-13 | 2025 | +3 | +27.0 | 43% | 19 |
| 32 | Vanderbilt over Virginia Tech 44–20 · on the road · 2025-09-06 | 2025 | +2 | +26.0 | 45% | — |
| 33 | Delaware over Florida International 38–16 · on the road · 2025-09-20 | 2025 | +4 | +26.0 | 40% | — |
| 34 | Wisconsin over Illinois 27–10 · at home · 2025-11-23 | 2025 | +8.5 | +25.5 | 30% | — |
| 35 | Stanford over California 31–10 · at home · 2025-11-23 | 2025 | +4.5 | +25.5 | 39% | — |
| 36 | Minnesota over #25Nebraska 24–6 · at home · 2025-10-18 | 2025 | +7 | +25.0 | 33% | 5 |
| 37 | Sam Houston over Oregon State 21–17 · on the road · 2025-11-09 | 2025 | +21 | +25.0 | 9% | — |
| 38 | Old Dominion over Virginia Tech 45–26 · on the road · 2025-09-13 | 2025 | +5.5 | +24.5 | 37% | — |
| 39 | Stanford over Florida State 20–13 · at home · 2025-10-19 | 2025 | +17.5 | +24.5 | 14% | — |
| 40 | #7Oregon over #23Texas Tech 23–0 · neutral site · 2026-01-01 | 2025 | +1.5 | +24.5 | 46% | — |
| 41 | Stanford over Boston College 30–20 · at home · 2025-09-14 | 2025 | +14 | +24.0 | 19% | — |
| 42 | Central Michigan over Bowling Green 27–6 · on the road · 2025-10-18 | 2025 | +3 | +24.0 | 43% | — |
| 43 | Coastal Carolina over Marshall 44–27 · at home · 2025-10-30 | 2025 | +7 | +24.0 | 33% | — |
| 44 | #12Vanderbilt over #18Tennessee 45–24 · on the road · 2025-11-29 | 2025 | +2.5 | +23.5 | 44% | — |
| 45 | Utah State over Air Force 49–30 · at home · 2025-09-14 | 2025 | +4 | +23.0 | 40% | — |
| 46 | West Virginia over #22Houston 45–35 · on the road · 2025-11-01 | 2025 | +13 | +23.0 | 21% | 8 |
| 47 | Washington State over Toledo 28–7 · at home · 2025-10-25 | 2025 | +1.5 | +22.5 | 46% | — |
| 48 | #20Virginia over Duke 34–17 · on the road · 2025-11-15 | 2025 | +5.5 | +22.5 | 37% | — |
| 49 | Washington State over Colorado State 20–3 · on the road · 2025-09-27 | 2025 | +4.5 | +21.5 | 39% | — |
| 50 | Northwestern over Penn State 22–21 · on the road · 2025-10-11 | 2025 | +20.5 | +21.5 | 10% | — |
| 51 | California over #14Louisville 29–26 · on the road · 2025-11-09 | 2025 | +18.5 | +21.5 | 12% | 16 |
| 52 | South Florida over #13Florida 18–16 · on the road · 2025-09-06 | 2025 | +18.5 | +20.5 | 12% | 17 |
| 53 | Arkansas State over Troy 23–10 · on the road · 2025-11-02 | 2025 | +7.5 | +20.5 | 32% | — |
| 54 | Florida over Florida State 40–21 · at home · 2025-11-29 | 2025 | +1.5 | +20.5 | 46% | — |
| 55 | Ball State over Ohio 20–14 · at home · 2025-10-04 | 2025 | +14 | +20.0 | 19% | — |
| 56 | Army over Kansas State 24–21 · on the road · 2025-09-06 | 2025 | +16.8 | +19.8 | 15% | — |
| 57 | East Carolina over Pittsburgh 23–17 · neutral site · 2025-12-27 | 2025 | +12.5 | +18.5 | 22% | — |
| 58 | Kentucky over Auburn 10–3 · on the road · 2025-11-01 | 2025 | +11.5 | +18.5 | 24% | — |
| 59 | Coastal Carolina over App State 45–37 · on the road · 2025-10-18 | 2025 | +10.5 | +18.5 | 26% | — |
| 60 | Akron over Buffalo 24–16 · on the road · 2025-10-25 | 2025 | +10 | +18.0 | 27% | — |