| 1 | Iowa State over Texas Tech 66–10 · at home · 2016-11-19 | 2016 | +3 | +59.0 | 43% | — |
| 2 | TCU over #13Baylor 62–22 · on the road · 2016-11-05 | 2016 | +9 | +49.0 | 29% | 17 |
| 3 | #10Louisville over #2Florida State 63–20 · at home · 2016-09-17 | 2016 | +4.5 | +47.5 | 39% | 8 |
| 4 | SMU over #11Houston 38–16 · at home · 2016-10-22 | 2016 | +24 | +46.0 | 7% | 19 |
| 5 | Colorado State over San Diego State 63–31 · on the road · 2016-11-27 | 2016 | +12.5 | +44.5 | 22% | — |
| 6 | Mississippi State over Ole Miss 55–20 · on the road · 2016-11-26 | 2016 | +8 | +43.0 | 31% | — |
| 7 | Akron over Marshall 65–38 · on the road · 2016-09-17 | 2016 | +15.5 | +42.5 | 17% | — |
| 8 | Nevada over UNLV 45–10 · on the road · 2016-11-26 | 2016 | +7 | +42.0 | 33% | — |
| 9 | Arkansas State over #25Troy 35–3 · on the road · 2016-11-18 | 2016 | +8.5 | +40.5 | 30% | 5 |
| 10 | UTSA over Middle Tennessee 45–25 · on the road · 2016-11-05 | 2016 | +19 | +39.0 | 12% | — |
| 11 | Washington State over #15Stanford 42–16 · on the road · 2016-10-09 | 2016 | +12.5 | +38.5 | 22% | 15 |
| 12 | Bowling Green over Kent State 42–7 · at home · 2016-11-16 | 2016 | +3 | +38.0 | 43% | — |
| 13 | UTSA over Southern Miss 55–32 · at home · 2016-10-08 | 2016 | +14.5 | +37.5 | 18% | — |
| 14 | Army over Temple 28–13 · on the road · 2016-09-02 | 2016 | +21.5 | +36.5 | 9% | — |
| 15 | #25Virginia Tech over #17North Carolina 34–3 · on the road · 2016-10-08 | 2016 | +5.5 | +36.5 | 37% | 8 |
| 16 | Tulsa over Memphis 59–30 · on the road · 2016-10-30 | 2016 | +7.5 | +36.5 | 32% | — |
| 17 | Marshall over Middle Tennessee 42–17 · at home · 2016-11-13 | 2016 | +11.5 | +36.5 | 24% | — |
| 18 | South Alabama over #19San Diego State 42–24 · at home · 2016-10-02 | 2016 | +17.5 | +35.5 | 14% | 11 |
| 19 | Buffalo over Akron 41–20 · at home · 2016-10-27 | 2016 | +14.5 | +35.5 | 18% | — |
| 20 | South Alabama over Mississippi State 21–20 · on the road · 2016-09-03 | 2016 | +34 | +35.0 | 2% | — |
| 21 | North Texas over Army 35–18 · on the road · 2016-10-22 | 2016 | +17.5 | +34.5 | 14% | — |
| 22 | #2Clemson over #6Ohio State 31–0 · neutral site · 2017-01-01 | 2016 | +3 | +34.0 | 43% | — |
| 23 | #20West Virginia over Texas Tech 48–17 · on the road · 2016-10-15 | 2016 | +1 | +32.0 | 48% | — |
| 24 | #21Oklahoma State over #17Colorado 38–8 · neutral site · 2016-12-30 | 2016 | +2 | +32.0 | 45% | 4 |
| 25 | California over UCLA 36–10 · at home · 2016-11-27 | 2016 | +5.5 | +31.5 | 37% | — |
| 26 | Richmond over Virginia 37–20 · on the road · 2016-09-03 | 2016 | +14 | +31.0 | 19% | — |
| 27 | Syracuse over #17Virginia Tech 31–17 · at home · 2016-10-15 | 2016 | +17 | +31.0 | 14% | 13 |
| 28 | Eastern Washington over Washington State 45–42 · on the road · 2016-09-04 | 2016 | +27.5 | +30.5 | 4% | — |
| 29 | Vanderbilt over Ole Miss 38–17 · at home · 2016-11-20 | 2016 | +9.5 | +30.5 | 28% | — |
| 30 | #11Wisconsin over #8Michigan State 30–6 · on the road · 2016-09-24 | 2016 | +6 | +30.0 | 35% | 3 |
| 31 | #13Oklahoma State over TCU 31–6 · on the road · 2016-11-19 | 2016 | +4.5 | +29.5 | 39% | — |
| 32 | UAlbany over Buffalo 22–16 · on the road · 2016-09-02 | 2016 | +23 | +29.0 | 8% | — |
| 33 | Charlotte over Southern Miss 38–27 · on the road · 2016-11-05 | 2016 | +18 | +29.0 | 13% | — |
| 34 | SMU over East Carolina 55–31 · on the road · 2016-11-12 | 2016 | +5 | +29.0 | 38% | — |
| 35 | Kentucky over #11Louisville 41–38 · on the road · 2016-11-26 | 2016 | +26 | +29.0 | 5% | 19 |
| 36 | #23Baylor over Boise State 31–12 · neutral site · 2016-12-28 | 2016 | +10 | +29.0 | 27% | — |
| 37 | Southern Miss over Louisiana Tech 39–24 · at home · 2016-11-25 | 2016 | +13.5 | +28.5 | 20% | — |
| 38 | Kansas State over TCU 30–6 · on the road · 2016-12-03 | 2016 | +4.5 | +28.5 | 39% | — |
| 39 | North Texas over Marshall 38–21 · at home · 2016-10-08 | 2016 | +11 | +28.0 | 25% | — |
| 40 | Stanford over Arizona 34–10 · on the road · 2016-10-30 | 2016 | +3 | +27.0 | 43% | — |
| 41 | Arizona over Arizona State 56–35 · at home · 2016-11-26 | 2016 | +6 | +27.0 | 35% | — |
| 42 | Tulane over UConn 38–13 · on the road · 2016-11-26 | 2016 | +2 | +27.0 | 45% | — |
| 43 | #25San Diego State over #15Houston 34–10 · neutral site · 2016-12-17 | 2016 | +3 | +27.0 | 43% | 10 |
| 44 | Wyoming over Colorado State 38–17 · on the road · 2016-10-02 | 2016 | +5.5 | +26.5 | 37% | — |
| 45 | UL Monroe over Georgia State 37–23 · on the road · 2016-11-12 | 2016 | +12.5 | +26.5 | 22% | — |
| 46 | Kent State over Buffalo 44–20 · on the road · 2016-10-08 | 2016 | +2 | +26.0 | 45% | — |
| 47 | Miami (OH) over Central Michigan 37–17 · at home · 2016-11-04 | 2016 | +6 | +26.0 | 35% | — |
| 48 | Auburn over Mississippi State 38–14 · on the road · 2016-10-08 | 2016 | +1.5 | +25.5 | 46% | — |
| 49 | Temple over #20Navy 34–10 · on the road · 2016-12-03 | 2016 | +1.5 | +25.5 | 46% | 10 |
| 50 | Hawai'i over Air Force 34–27 · on the road · 2016-10-22 | 2016 | +17.5 | +24.5 | 14% | — |
| 51 | Arkansas over #10Florida 31–10 · at home · 2016-11-05 | 2016 | +3.5 | +24.5 | 41% | 20 |
| 52 | Georgia Tech over #18Virginia Tech 30–20 · on the road · 2016-11-12 | 2016 | +14.5 | +24.5 | 18% | 12 |
| 53 | UCLA over Arizona 45–24 · at home · 2016-10-02 | 2016 | +3 | +24.0 | 43% | — |
| 54 | Minnesota over Maryland 31–10 · on the road · 2016-10-15 | 2016 | +3 | +24.0 | 43% | — |
| 55 | Kansas over Texas 24–21 · at home · 2016-11-19 | 2016 | +21 | +24.0 | 9% | — |
| 56 | Idaho over Colorado State 61–50 · neutral site · 2016-12-23 | 2016 | +13 | +24.0 | 21% | — |
| 57 | Duke over Notre Dame 38–35 · on the road · 2016-09-24 | 2016 | +20 | +23.0 | 11% | — |
| 58 | Penn State over #2Ohio State 24–21 · at home · 2016-10-23 | 2016 | +20 | +23.0 | 11% | 28 |
| 59 | Navy over #6Houston 46–40 · at home · 2016-10-08 | 2016 | +17 | +23.0 | 14% | 24 |
| 60 | USC over #4Washington 26–13 · on the road · 2016-11-13 | 2016 | +10 | +23.0 | 27% | 26 |